New lupus research has advanced our
understanding of lupus and has helped discover new
treatments for the disease.
In the first diagnostic breakthrough in
40 years, lupus research has resulted in a new screening
test for systemic lupus erythematosus that will help
diagnose 20% more cases of SLE.
Northwestern Memorial Hospital in Chicago
was the first to do a stem cell transplant in the
treatment of lupus. This lupus research is showing
promise in treating patients who do not respond to
current treatments.
Lupus research on autoimmunity using mice
is being done on signal pathways of the Fas gene and its
inhibitor cFLIP.
New lupus research has been done which
has identified new information about BAFF(B cell
activation factor) and BAFF-r (the receptor protein).
BAFF is a key protein in the development of lymphocytes
and BAFF-r is a key target associated with abnormal B
lymphocyte activity.
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Human Genome Sciences is doing lupus
research on the B Lymphocyte Stimulator (BLyS) which may
be a sensitive marker of lupus disease. The drug,
LymphoStat-B, is in the first phase of trials and works
by binding to BLyS and inhibiting stimulation of B cell
development and proliferation.
At the present time, lupus research is
focusing on trying to find the answers to the following
questions:
-
How
can the malfunctioning immune system be repaired?
-
Why
do certain ethnic and racial groups more likely to
get lupus?
-
Why
are more women than men stricken with lupus?
-
Who
are the people that get lupus and why do they get
it?
-
What
is the best way to treat the symptoms of lupus?
-
What
goes wrong with the immune system and why does it go
wrong?
-
What
are the genes that predispose a person to lupus?
Help Your Body Heal Itself
The new research studies on lupus
include: A study using mice to discover genes that cause
neurological symptoms of lupus so that targeted
therapies can be developed; a study on the mechanism of
brain dysfunction in SLE; a study on cognitive
dysfunction in neuropsychiatric SLE which will suggest
new treatment targets; a study on cognitive dysfunction
and biological changes in patients with lupus who have
neuropsychiatric symptoms ; and a study using mice on
the mechanisms that cause cell death in the brain of the
mice with lupus neuropsychiatric symptoms and a study of
how the malfunctioning nervous system affects behavior.
Many research studies are being done on
lupus which will increase our understanding of the
disease, improve treatments and possibly lead to a cure
in the future. Much more lupus research still needs to
be done, however, and it cannot go forward without
adequate funding so people should be sure to write to
their congressmen telling them to fund lupus research.
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