Antiphospholipid syndrome is an immune
disorder that can affect virtually any organ.
Antiphospholipid syndrome involves abnormal tendency
toward clotting of blood. Antiphospholipid syndrome,
also referred to as Hughes syndrome and Sticky Blood, is
a disorder of the immune system that is characterized by
excessive clotting of blood, certain pregnancy
complications and antiphospholipid antibodies.
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Patients with antiphospholipid
syndrome have developed abnormal symptoms while having
antiphospholipid antibodies detectable in the blood.
However, the antiphospholipid antibody is not considered
a normal blood protein. The antiphospholipid antibody
has been found in patients to be associated with a
number of illnesses including thrombosis, stroke,
phlebitis, miscarriages, abnormally low blood platelet
counts and migraine headaches. Antiphospholipid
antibodies have also been detected in over half of
patients with systemic lupus erythematosus.
The cause of antiphospholipid syndrome and the cause of
lupus are not completely known. Both autoimmune diseases
are more common in women.
When only the symptoms of the antiphospholipid syndrome
occur, the condition is known as primary
antiphospholipid syndrome. The secondary form occurs in
association with another autoimmune disease, usually
systemic lupus erythematosus.
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Patients with underlying systemic
lupus erythematosus may report lupus symptoms including
the "butterfly" rash on the cheeks, sensitivity to
sunlight, joint pains, excessive hair loss, dry eyes,
cold and bluish fingers, and mouth ulcers.
A simple blood test can detect the 'antiphospholipid
antibodies'. Other blood tests can check for underlying
conditions, such as lupus. Each individual patient with
the antiphospholipid syndrome is treated uniquely
according to what symptoms are present.
It is important to note that antiphospholipid antibodies
can also be found in the blood of individuals without
any disease process. In fact, antiphospholipid
antibodies have been reported in approximately 2 percent
of the normal population. Harmless antiphospholipid
antibodies can be detected in the blood for a brief
period occasionally in association with a wide variety
of conditions, including bacterial, viral and parasite
infections. Certain drugs can also cause
antiphospholipid antibodies to be produced in the blood.
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