All three glucosamine salts contain the same general components and it is believed that all produce the same general effects in the body. However, no studies have compared them so not enough information is available about potential differences in their activity to know whether they are interchangeable. Most of the clinical studies investigating the medical effects of glucosamine used glucosamine sulfate.

Even though most studies of glucosamine used glucosamine sulfate, there is no evidence to suggest that glucosamine sulfate offers advantages over glucosamine hydrochloride hcl or N-Acetyl Glucosamine.

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N-acetyl glucosamine (NAG) is a form of glucosamine that differs from glucosamine sulfate and glucosamine hydrochloride hcl. Instead of a sulfur or chloride molecule, N-acetyl glucosamine has a larger, more complex molecule attached to it. As a result, NAG is an entirely different molecule than either glucosamine sulfate or hydrochloride, and it also appears to be handled by the body differently.

N-Acetyl Glucosamine is the body’s precursor to hyaluronic acid, which is part of the synovial fluid that lubricates joints. N-Acetyl Glucosamine is the versatile form of glucosamine for joint and intestinal tissue.

It is believed that N-acetyl glucosamine increases the production of mucus that lines the lower gastrointestinal tract and provides a protective effect. In a few small studies, n-acetyl glucosamine has shown promise for treating inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.

Glucosamine hydrochloride (glucosamine hcl) offers the promise of the same efficacy as glucosamine sulfate, though there are few completed studies on glucosamine hcl to review. The glucosamine hydrochloride form is touted as more available to absorption into the body and is more concentrated than the glucosamine sulfate form.

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Glucosamine sulfate is the form that has been tested in dozens of clinical trials. It is very similar to glucosamine hcl (hydrochloride) in effectiveness, because the sulfate is simply a carrier molecule for the actual glucosamine.

Glucosamine sulfate alone is fine but glucosamine sulfate NaCL or Kcl should be avoided. The NaCl and KCl refer to added carrier molecules. These add to the product's weight without giving added benefit.

Basically, the body doesn’t care how it gets glucosamine as long as it is bio-available. While comparing glucosamine N-Acetyl to glucosamine hydrocloride and glucosamine sulfate, it is also important to not only look at the glucosamine form but the quality of that particular ingredient.

There is high quality N-Acetyl Glucosamine and low quality N-Acetyl Glucosamine. There is high quality Glucosamine hydrocloride and low quality Glucosamine hydrocloride. The same goes for glucosamine sulfate. Buying from a reputable manufacturer with high manufacturing standards is the best way of receiving a quality product.

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