The following information is intended to supplement, not substitute, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that using Anafranil is safe or appropriate for you.

People seeking depression relief should carefully evaluate Anafranil information and side effects before deciding to take Anafanil. Consult your healthcare professional before using Anafranil.

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What is Anafranil used for? Anafranil is in a class of drugs called tricyclic antidepressants. Clomipramine is used to relieve symptoms of depression and obsessive-compulsive disorder.

General Anafranil Precautions:

_ Do not take clomipramine if you have taken a monoamine oxidase inhibitor (MAOI) within the last 14 days.

_ Clomipramine may cause drowsiness, dizziness, or blurred vision. If you experience drowsiness, dizziness, or blurred vision, avoid driving, operating machinery, or performing other hazardous activities.

_ You are more likely to experience side effects from clomipramine if you are over the age of 60.

_ Rise slowly when rising from a sitting or lying position to prevent dizziness or possible falls.

_ If you skip the missed dose and take only the next one as directed. Do not take a double dose of this medication. Overdose is possible.

_ Anafranil may impair judgment, thinking, or motor skills. Patients using Anafranil should exercise caution until they have adapted to therapy.

_ It is not known whether clomipramine will harm an unborn baby or a nursing baby.

Anafranil can cause serious side effects. Only you can decide if Anafranil is the best means of treating depression symptoms. It is important to discuss the side effects of Anafranil with your physician.

Anafranil Side Effects:

_ High blood pressure.

_ Difficulty urinating.

_ Fever with increased sweating, muscle stiffness, or severe muscle weakness.

_ Seizures.

_ Fast or irregular heartbeat.

_ Heart attack.

_ Agitation.

_ Weakness.

_ Ringing in the ears.

_ Tremors (shaking) or muscle twitches.

_ Decreased appetite.

_ Abdominal pain.

_ Nausea.

_ Headache.

_ Dizziness or drowsiness.

_ Constipation.

_ Dry mouth and eyes.

_ Blurred vision.

Contact your doctor immediately if you experience: An allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives). Stop taking Anafranil and contact your doctor immediately or seek emergency medical treatment if you also experience seizures, a fast or irregular heartbeat, high blood pressure (blurred vision, headache), a heart attack, fever with increased sweating, muscle stiffness, or severe muscle weakness or difficulty urinating. Contact your doctor immediately if you experience yellowing of the skin or eyes.

Before taking Anafranil, tell your doctor if you have or have had:

_ Asthma.

_ Thyroid disease.

_ High blood pressure.

_ Heart disease.

_ Had a heart attack in the last 6 weeks.

_ Stomach or intestinal problems.

_ An enlarged prostate or difficulty urinating.

_ Liver disease.

_ Kidney disease.

_ Diabetes.

_ Glaucoma.

_ Seizures.

What should I avoid while taking clomipramine?

_ Grapefruit and grapefruit juice may interact with clomipramine and could lead to potentially dangerous effects.

_ Use alcohol cautiously while taking clomipramine. Alcohol may increase drowsiness and dizziness.

Symptoms of Anafranil overdose may include: Symptoms of a clomipramine overdose include confusion, drowsiness, dizziness, fatigue, seizures, agitation, low blood pressure, fainting and hallucinations.

What other drugs will affect clomipramine? Clomipramine can increase the effects of many other drugs, leading to serious side effects. If taking Anafranil, talk to your doctor and pharmacist before taking drugs that cause drowsiness including other antidepressants, alcohol, antihistamines, sedatives, pain relievers, anxiety medicines, and muscle relaxants.

*This antidepressant drug information does not endorse Anafranil, diagnose patients or recommend therapy. The information contained herein is not intended to cover all possible warnings, uses, precautions, drug interactions, allergic reactions, or adverse side effects of Anafranil. If you have questions about the drugs you are taking, check with your health care provider or pharmacist. The information provided should not be construed to indicate that Anafranil is safe, effective or appropriate.

Do not stop taking Anafranil without first talking to your doctor. Your doctor may need to gradually reduce the dose before stopping Anafranil completely. Suddenly stopping Anafranil can cause unpleasant and potentially serious side effects.